Left Right Patterning, Evolution and Cardiac Development
نویسندگان
چکیده
منابع مشابه
Left Right Patterning, Evolution and Cardiac Development
Many aspects of heart development are determined by the left right axis and as a result several congenital diseases have their origins in aberrant left-right patterning. Establishment of this axis occurs early in embryogenesis before formation of the linear heart tube yet impacts upon much later morphogenetic events. In this review I discuss the differing mechanisms by which left-right polarity...
متن کاملLeft-right patterning: conserved and divergent mechanisms.
The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea...
متن کاملVertebrate left-right development
Significant biological asymmetries range from the differentiation of sides within a single cell to the establishment of embryonic pattern across large fields of cells in multicellular organisms. One of the most intriguing biological asymmetries is left-right asymmetry in vertebrates. All vertebrates display a number of structures that are asymmetric along the left-right geometric body axis. The...
متن کاملLeft-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease.
Proper morphogenesis and positioning of internal organs requires delivery and interpretation of precise signals along the anterior-posterior, dorsal-ventral, and left-right axes. An elegant signaling cascade determines left- versus right-sided identity in visceral organs in a concordant fashion, resulting in a predictable left-right (LR) organ asymmetry in all vertebrates. The complex morphogen...
متن کاملCelf1 regulation of dmrt2a is required for somite symmetry and left-right patterning during zebrafish development.
RNA-binding proteins (RBPs) bind to numerous and diverse mRNAs to control gene expression post-transcriptionally, although the in vivo functions of specific RBP-mRNA interactions remain largely unknown. Here, we show that an RBP named Cugbp, Elav-like family member 1 (Celf1) controls expression of a gene named doublesex and mab-3 related transcription factor 2a (dmrt2a), which is essential for ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cardiovascular Development and Disease
سال: 2014
ISSN: 2308-3425
DOI: 10.3390/jcdd1010052